Living on Overtime, David C. Fajgenbaum

Sep 18, 2019 Episode Page ↗
Overview

Dr. David Fajgenbaum, Assistant Professor at Penn Medicine and co-founder of the Castleman Disease Collaborative Network, shares profound life lessons gleaned from his five near-death experiences with a rare illness. He discusses living "on overtime," turning hope into action, and the power of love and humor, offering scalable wisdom for all.

At a Glance
15 Insights
1h 10m Duration
14 Topics
5 Concepts

Deep Dive Analysis

Introduction to David Fajgenbaum and Castleman Disease

David's First Near-Death Experience and Regrets

Reconciling with Caitlin Amidst Illness

Understanding Idiopathic Multicentric Castleman Disease

Commitment to Curing Castleman Disease

Progress in Castleman Disease Research and Treatment

Living Life 'On Overtime' and the 'Think It, Do It' Motto

Turning Hope into Action and Creating Silver Linings

Sustaining Urgency and the Role of Mindfulness

The Meditative Walk to and from Work

The Power of Humor in Adversity

Re-evaluating Diet and Embracing Uncertainty

The Profound Importance of Love and Support

Caitlin's Perspective on Love and Commitment

Idiopathic Multicentric Castleman Disease (iMCD)

A rare and severe illness that is a cross between an autoimmune disease and a cancer. The immune system gets completely out of control, attacking and shutting down vital organs like the liver, heart, lungs, and kidneys.

Living on Overtime

A mental model for life, inspired by near-death experiences, where one recognizes that every second counts. It encourages living with clarity and purpose, making the most of every moment as if it's borrowed time, because none of us truly know how much time we have.

Think It, Do It

A motto to overcome the internal 'naysayer' and act on important thoughts or feelings. If you think about something important you want to do or say, do it, rather than waiting for a 'right time' or talking yourself out of it.

Turn Hope into Action

The principle that hoping, praying, or wishing for something is not enough. If something is truly important to you, it should drive your actions to actively work towards making it happen, rather than passively waiting for it to materialize.

Creating Silver Linings

An approach to adversity where, instead of merely looking for a positive outcome from a tough experience, one actively creates positive outcomes or meaning from the challenges faced. It's about transforming personal storms into something beneficial for others.

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What is idiopathic multicentric Castleman disease?

It's a rare and deadly illness, similar to a cross between an autoimmune disease and a cancer, where the immune system attacks and shuts down vital organs.

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How rare is Castleman disease?

It's very rare, with about 5,000 patients diagnosed each year in the U.S., which is comparable to the incidence of ALS.

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What did David Fajgenbaum regret on his deathbed?

He regretted the things he had not done or said, specifically not fighting for his relationship with Caitlin and not telling her how he felt.

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How can one sustain urgency in life, even without a near-death experience?

Hearing stories from others who have faced extreme challenges can help internalize the idea that everyone is 'in overtime' and should live with purpose and clarity.

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How can humor help during difficult times, like severe illness?

Humor can provide critical relief and a sense of normalcy, helping patients and their loved ones cope with grim situations and reminding them of who they are beyond their illness.

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What did David Fajgenbaum learn about diet and control from his illness?

He learned that hyper-focusing on a perfectly healthy diet and exercise didn't prevent his serious disease, suggesting that one doesn't have control over everything and should embrace life's uncertainties, finding a middle ground rather than strict adherence.

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What is the significance of love and support during a life-threatening illness?

Love and support from friends and family provide an unparalleled source of strength, helping individuals get through difficult times and motivating them to fight for a longer life.

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Is it okay to meditate lying down?

Yes, lying down is one of the four traditional meditation postures, and it's perfectly acceptable to practice this way, especially if it's the only time available or if it helps sustain attention without falling asleep.

1. Think It, Do It

If you think about something important you want to do or say, act on it immediately. Do not talk yourself out of it or wait for a perfect future moment, as life’s uncertainty means every second counts.

2. Turn Hope Into Action

Do not merely hope, pray, or wish for things to happen; if something is important enough to hope for, let that desire drive you to take concrete actions to make it a reality.

3. Live Life On Overtime

Recognize that none of us know how much time we have, so live every second with clarity and purpose, as if you are in ‘overtime’ where every moment is critical and must be made the most of.

4. Focus on Purpose & People

When facing life’s challenges, prioritize your core purpose (e.g., meaningful work) and the people you love, as these provide essential strength, motivation, and are the most important things in the world.

5. Create Silver Linings

Instead of passively looking for positive outcomes from tough times, actively create positive opportunities or movements from difficult experiences. This transforms challenges into something meaningful and impactful.

6. Transcending Self-Focus

Shift your focus outwards, beyond personal desires, to causes or people bigger than yourself. This outward orientation can be liberating, adding power and energy to your life and reducing suffering.

7. Never Decline Family Time

Make it a priority to spend time with your family whenever possible. These moments are precious, and you may regret not having taken those opportunities later in life.

8. Ask ‘What Matters Most?’

When contemplating your life or making decisions, use the phrase ‘what matters most’ to guide your thoughts. This helps to focus on core priorities like family and love, cutting through less significant worries.

9. Embrace Humor in Adversity

Utilize humor as a critical and powerful tool to navigate extremely tough times, even when facing death. It can provide essential relief and help both you and your loved ones cope with difficult situations.

10. Ritualize Commute for Transition

Use your commute, such as a walk, as a ritualistic ‘reset’ period to mentally transition between different modes of life (e.g., professional to personal). This helps you prepare for the next phase with greater presence and intention.

11. Practice the ‘Middle Way’

Avoid extreme or hyper-focused approaches in life, such as overly strict diets, and instead embrace a ‘gray area’ of flexibility and balance. Recognize that you don’t control everything and that life isn’t always black or white.

12. Confront Difficult Emotions in Meditation

It is beneficial to deal forthrightly with and clearly observe difficult thoughts and emotions within the structured ‘container’ of meditation. This approach is better than allowing them to stew unconsciously and drive your actions blindly.

13. Start Meditation Slowly

If you are new to meditation or experiencing distress, approach the practice slowly and with self-care. Begin with short periods, such as five minutes a day, to gradually build confidence and interest.

14. Try Walking Meditation for Distress

When feeling distressed, consider practicing walking meditation as an alternative to sitting. Directing attention externally during a walk can make it easier to manage difficult internal thoughts and emotions.

15. Meditate While Lying Down

It is perfectly acceptable to meditate while lying down, especially if it’s the only time or way you can practice effectively without falling asleep. The key is to sustain attention, and lying down is a traditional posture.

I didn't regret a single thing that I had done or that I had said. I only regretted the things that I had not done, had not said, and that I wouldn't be able to do in the future.

David Fajgenbaum

If I think it, I'm going to do it.

David Fajgenbaum

I'm going to dedicate the rest of my life, however long that may be, to trying to cure this disease.

David Fajgenbaum

There are 1,500 drugs already FDA approved for something. And there are 7,000 diseases that don't have any FDA approved drugs. So the really important question is how many of these 1,500 already FDA approved drugs might actually be treatments or cures for a disease that doesn't have any options.

David Fajgenbaum

Buddhism is not something you believe in. It's something you do.

Dan Harris

Never turn down an opportunity to spend time with your family.

Lucy (Mexican mom, quoted by Dan Harris)

My book's called chasing my cure, but it's not my cure that I'm chasing. It's, it's our cure.

David Fajgenbaum

Everything is perfect, but it can use a little improvement.

Dan Harris

Say goodbye to your little friends.

Dan Harris's wife (quoted by Dan Harris)

What matters most.

Dan Harris (quoting his meditation teacher)

Daily Transition Ritual

David Fajgenbaum
  1. Take a 40-minute walk to work in the morning to prepare for the day's tasks.
  2. Take a 40-minute walk home in the evening to transition from work mode to family time.
  3. Use these walks as a 'reset' to shift focus and be fully present in each mode of life.
5,000
Patients diagnosed with Castleman disease annually in the U.S. About as common as ALS.
$1 million
Investment by the Castleman Disease Collaborative Network (CDCN) into research over seven years Resulted in an additional $7 million from external funders.
1,500
FDA-approved drugs for any condition
7,000
Diseases without any FDA-approved drugs
5.5 years (67.7 months)
Duration David Fajgenbaum has been in remission on his self-discovered drug After 5 flares in the first 3.5 years.
24
Number of patients in the clinical trial for David's drug Other patients who don't get better on the approved drug.
5 times
Number of times David Fajgenbaum nearly died
Almost six months
Duration of David's first hospitalization
50 pounds
Weight gain due to fluid accumulation during David's illness
1 year old
Age of David's daughter, Amelia