What is psychosomatic illness? (with Suzanne O'Sullivan)

Nov 12, 2025 Episode Page ↗
Overview

Dr. Suzanne O'Sullivan, a neurologist and clinical neurophysiologist, discusses long COVID, arguing that a significant portion of cases are psychosomatic. She explains how psychological mechanisms, attention, and expectation can manifest as real, disabling physical symptoms, and how to approach such conditions.

At a Glance
8 Insights
1h 49m Duration
16 Topics
5 Concepts

Deep Dive Analysis

Misunderstanding Long COVID: Neglected Psychosomatic Aspects

Defining Post-Viral Illness and Psychosomatic Conditions

The Role of Anxiety and Expectation in Symptom Creation

Scientific Evidence for Psychosomatic Long COVID

Personal Anecdote: Anxiety Manifesting as Physical Symptoms

How Attention, Expectation, and Emotion Create Symptoms

Extreme Manifestations of Psychosomatic Illness: Seizures and Paralysis

Challenges in Treating Long-Standing Psychosomatic Conditions

Understanding Chronic Pain and Unexplained Symptoms

Mindfulness vs. Distraction for Managing Physical Symptoms

The Controversy and Misdiagnosis of Chronic Lyme Disease

Functional Disorders: Renaming and Stigma

Cultural Perspectives on Illness: Greasy Sickness Example

Navigating Unexplained Symptoms: When to Stop Testing

Therapeutic Approaches for Chronic Unexplained Symptoms

Supporting Friends and Family with Unexplained Illnesses

Psychosomatic Condition

Psychosomatic conditions involve real, disabling physical symptoms that arise more from psychological mechanisms like ideas about illness, fear, and how one feels about their body, which changes brain connections. It does not mean symptoms are imagined or faked, but rather originate from the mind-body interaction rather than direct physical damage.

Post-viral Illness

A post-viral illness is a chronic fatigue-like condition that can follow a viral infection, lasting for six months or longer. While its mechanism is not fully understood, it is usually self-limiting and most people recover, though it may have a psychosomatic element in some cases.

Nocebo Effect

The nocebo effect is the opposite of the placebo effect, where negative expectations about a treatment or condition can lead to negative outcomes or symptom development. If one expects a virus to cause long-term disability, there is a chance that expectation can contribute to the actual manifestation of symptoms.

Functional Disorder

A functional disorder is a term used in medicine to describe conditions where there are physical symptoms but no clear structural or organic cause found on tests. It is a re-labeling of what was previously called psychosomatic or hysterical conditions, intended to destigmatize, but can obscure the underlying psychological mechanisms.

Culture-Bound Syndromes

Culture-bound syndromes are particular collections of symptoms that occur for specific reasons within small communities, often with culturally specific explanations and solutions. These syndromes, like 'greasy sickness,' can have mechanisms similar to psychosomatic conditions but are interpreted and resolved through cultural frameworks.

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How does Dr. O'Sullivan categorize the different potential causes of 'long COVID' symptoms?

Dr. O'Sullivan suggests four main categories: lasting organ damage from severe COVID, a general post-viral illness (like chronic fatigue), misattribution of unrelated new conditions to COVID, and psychosomatic conditions where psychological mechanisms drive real physical symptoms.

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What is the primary difference between long COVID and severe COVID patient populations?

People who died of severe COVID tended to be frail, elderly, or have comorbid illnesses, while people with long COVID symptoms often tended to be extra healthy before the pandemic, with a higher prevalence among younger women, suggesting distinct populations.

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What evidence supports the psychosomatic theory for many long COVID cases?

Evidence includes a significant disparity between the severity of reported symptoms and normal objective test findings, studies showing that an expectation of symptom severity and pre-morbid psychiatric symptoms increase risk, and the observation that initial long COVID concepts arose from social media rather than scientific consensus.

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How can attention and expectation influence physical symptoms?

Paying undue attention to bodily sensations can make normal 'white noise' sensations feel abnormal, and anxiety can activate the fight-or-flight system, producing more symptoms. The brain's predictive nature means that expecting certain symptoms can actually make them manifest, similar to the nocebo effect.

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What is the typical trajectory of a psychosomatic illness, from onset to severe manifestation?

It often starts with an explainable physical event (e.g., fainting) followed by fear and anxious attention to the body. This leads to the body behaving as expected (e.g., having a seizure), and if reinforced, can escalate to frequent, severe symptoms like hundreds of seizures a day or paralysis, often exacerbated by medical interventions like excessive testing.

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How does chronic Lyme disease relate to psychosomatic conditions and misdiagnosis?

Chronic Lyme disease is often a misdiagnosis for chronic, nonspecific symptoms, with many patients testing positive only through labs that use overly sensitive or non-specific antibody tests. Like long COVID, it can become a convenient explanation for suffering, drawing people into an 'industry' of non-mainstream treatments.

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Why is the term 'functional disorder' used, and what are its potential drawbacks?

The term 'functional disorder' is used to destigmatize conditions previously called psychosomatic or hysterical, by implying a problem with brain function rather than psychological issues. However, Dr. O'Sullivan fears it obscures the underlying causes, makes the problem seem concrete and harder to change, and may eventually become stigmatized itself.

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What should someone do if they have mysterious, chronic pains that doctors cannot diagnose?

It's crucial to find a trusted doctor who can help determine when 'enough tests is enough' to avoid false positives and the anxiety of waiting for results. Additionally, it's important to shift focus away from bodily symptoms by finding purpose outside of the illness, and consider physical and psychological rehabilitation.

1. Limit Excessive Medical Testing

If experiencing mysterious symptoms, find a trusted doctor to help determine when enough tests are enough. Excessive testing can lead to false positives, incidental findings, and increased anxiety, which can exacerbate symptoms.

2. Shift Focus from Bodily Symptoms

Actively find a purpose or focus outside of your bodily symptoms and concerns. A great deal of what perpetuates symptoms is the anxious attention paid to them, so redirecting focus can be helpful for recovery.

3. Challenge Symptom Expectations

Learn and apply distraction techniques to break the brain’s predictive patterns for symptoms. If you expect symptoms to progress in a certain way, your brain can make it happen, so force symptoms in a different direction.

4. Engage with a Good Therapist

Seek psychological rehabilitation with a psychologist, psychotherapist, or psychoanalyst. A good therapist can help manage anxiety, understand emotions, and develop coping strategies, even if the disorder isn’t purely psychological.

5. Practice Non-Reactive Symptom Awareness

Develop a different relationship with your symptoms by noticing them without interpreting them as inherently wrong or bad. This mindfulness approach can reduce stress and frustration, potentially improving your ability to function.

6. Address Fear-Avoidance Patterns

Identify and challenge situations or activities you are avoiding due to fear of symptoms. Breaking these fear-avoidance cycles, often with the help of a psychologist, is crucial for recovery and regaining function.

7. Seek Physical Rehabilitation

If physical symptoms are present, engage in physical rehabilitation with physiotherapists and occupational therapists. This can help re-learn physical functions that may have been ‘unlearned’ due to psychological mechanisms.

8. Support Others without Confrontation

When supporting friends or family with these disorders, avoid confronting their personal theories about their illness or immediately suggesting psychological mechanisms. Instead, encourage a return to normality in a non-confrontational way to avoid alienating them.

If you tell people to examine their body for symptoms, you will find them because our bodies are awash with funny sensations.

Suzanne O'Sullivan

The concept of long COVID arose on Twitter. It didn't rise out of science or any medical establishment.

Suzanne O'Sullivan

Our bodies are really vulnerable to expectations and anxiety and the attention we pay to them. And you don't have to be a psychologically vulnerable person for that to happen. You just need to be in the right circumstance.

Suzanne O'Sullivan

If you expect that contracting a virus will lead to this type of long-term disability, then there is a small chance that that could actually happen to you.

Suzanne O'Sullivan

It's illness sometimes is a story you told yourself. And you need to tell yourself a story that will make you better to get better.

Suzanne O'Sullivan

It doesn't matter what you call it if you can de-stigmatize the concept.

Suzanne O'Sullivan

If we're just changing the name, then it's just an ever-ending, never-ending race to get the next stigmatized word.

Suzanne O'Sullivan

If people get better, I don't care what makes them better. Well, I mean, I do care. There's a limit, obviously, to what I'm willing to accept, what kind of treatment to make people better.

Suzanne O'Sullivan
30%
Chance of remission for late-diagnosed psychosomatic seizures If not diagnosed quickly, the pattern becomes deeply reinforced, making recovery significantly harder.
About a third
Proportion of medical consultations for common psychosomatic symptoms (dizziness, headaches, palpitations, shortness of breath) Refers to simpler cases of psychosomatic conditions.
85%
Percentage of chronic Lyme disease diagnoses considered misdiagnoses by a reputable clinic Based on a study where a university-affiliated hospital re-tested patients with existing Lyme diagnoses from other sources.
Half a million
Number of people in Australia who believe they have contracted Lyme disease Despite Australia's climate being inhospitable to Lyme-carrying ticks and the government stating the bacteria has never been identified there.