Most Replayed Moment: Are You Really Gluten Intolerant? It Could Be This Instead!

Jul 10, 2026 Transcript ↗
Overview

Dr. Will Bulsiewicz, a leading gastroenterologist, explains that common gut symptoms like bloating and gas are often misunderstood, revealing that the true trigger is frequently fructans, not gluten, and emphasizing the critical role of the microbiome in digestion and long-term health.

At a Glance
5 Insights
19m 57s Duration
12 Topics
7 Concepts

Deep Dive Analysis

Defining Chronic Gut Discomfort and Bloating

Understanding Constipation Beyond Frequency

Microbiome's Role in Stool Composition and Gas Production

Primary Causes of Gas and Bloating

The Distinction Between Gluten and Fructan Intolerance

Impact of Glyphosate on Wheat and Gut Health

Benefits of Sourdough Fermentation for Fructan Reduction

Common Foods Containing Fructans

Gut Repair and Dysbiosis in Inflammatory Bowel Disease

Immune System's Interaction with the Microbiome

Genetic and Environmental Factors in IBD Development

Antibiotics and Increased Risk of Inflammatory Bowel Disease

Constipation

Constipation is defined as the inadequate or incomplete emptying of bowels, which can manifest as infrequent bowel movements or partial poops where one doesn't feel fully relieved, even after multiple attempts.

Motility

Motility refers to the rhythmic movement of the intestines. Optimal gut health requires a consistent, predictable rhythm; too fast leads to diarrhea, while too slow results in constipation.

Microbiome

The microbiome is the community of microorganisms, primarily bacteria, residing in the gut. It constitutes 60% of stool weight, processes fiber using enzymes humans lack, and is crucial for overall gut function.

Dysbiosis

Dysbiosis describes a damaged or imbalanced gut microbiome where the microbes are weak and struggle to perform their functions, leading to issues like inefficient digestion, gas, and bloating.

Fructans

Fructans are carbohydrates found in foods like wheat, barley, rye, garlic, and onions. While beneficial prebiotics, they can cause gas and bloating in individuals with a sensitive gut, often mistakenly attributed to gluten intolerance.

Glyphosate

Glyphosate, a weed killer (Roundup), is sprayed on conventional wheat in the US to dry it quickly. It disrupts the gut microbiome by depleting beneficial bacteria and promoting inflammatory ones, as gut microbes lack the human workaround for its effects.

Inflammatory Bowel Disease (IBD)

IBD, including ulcerative colitis and Crohn's disease, is a condition where the immune system mistakenly attacks the gut microbiome, perceiving it as an enemy, leading to inflammation and damage in the intestines.

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Does any bloating or discomfort mean something is wrong with my gut?

Not necessarily, as occasional bloating is normal. However, if it's prolonged, chronic, or causes daily concern, it indicates a problem that requires attention.

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What is the true definition of constipation?

Constipation is the inadequate or incomplete emptying of your bowels, which can include infrequent bowel movements or partial poops where you don't feel fully relieved, even if you go multiple times a day.

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Why does gas often accompany constipation?

Gas travels with poop because when stool is in gridlock due to constipation, gut microbes have more time to ferment food particles and produce gas, which then gets trapped.

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What is the main component of human stool?

Your stool is predominantly your microbiome; 60% of its weight is microbial, meaning it's made up of bacteria.

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What are the primary causes of gas and bloating?

The main causes include poor gut motility (like constipation), a damaged microbiome (dysbiosis) struggling to process fiber, and certain dietary components such as lactose or fructans.

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Why do some people experience gut issues after eating wheat or gluten?

Often, the issue is not gluten itself but rather fructans, which are carbohydrates also present in wheat, barley, and rye. Additionally, glyphosate used in conventional wheat processing can disrupt the gut microbiome.

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Why might wheat be tolerated better in Italy compared to the United States?

In the United States, wheat is frequently sprayed with glyphosate (Roundup) to dry it quickly, a practice not common in Italy. This chemical can disrupt the gut microbiome, potentially causing adverse reactions.

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What happens to the gut microbiome during its development?

The microbiome is largely built during the first three years of life, reaching an adult-sized state. During this period, the immune system learns to recognize and interact with these microbes as friendly.

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Can Inflammatory Bowel Disease (IBD) be developed at any age?

Yes, IBD can develop at any age, even in individuals who are currently healthy, due to a combination of genetic predispositions and environmental factors.

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How do antibiotics impact the risk of developing IBD?

Taking antibiotics can double the risk of developing an inflammatory bowel disease in the following year, as they decimate gut diversity, disrupt the gut barrier, and activate the immune system.

1. Address Chronic Gut Discomfort

If you consistently wake up hoping for a good day without a specific gut issue, it indicates a chronic problem that needs to be addressed rather than dismissed as normal.

2. Understand True Constipation

Constipation is not solely about infrequent bowel movements; it also includes inadequate or partial emptying of the bowels, even if you poop daily, which can lead to gas and bloating.

3. Choose Organic Wheat Products

Opt for organic wheat products to avoid glyphosate (Roundup), a weed killer used in conventional farming that can disrupt your gut microbiome by depleting beneficial bacteria and promoting inflammatory ones.

4. Try Sourdough for Wheat Sensitivity

If you experience gut issues with regular wheat, try sourdough bread because its fermentation process significantly reduces fructan content, which is often the true trigger for symptoms rather than gluten itself.

5. Limit Antibiotic Use

Be cautious with antibiotics as they can severely disrupt the gut microbiome, reduce diversity, damage the gut barrier, and significantly increase the risk of developing inflammatory bowel diseases.

Your poop is predominantly your microbiome. 60% of the weight of your stool is microbial.

Dr. Will Bulsiewicz

We have been taking this concept of gluten intolerance and we've we've misnamed it. It's not a gluten intolerance, it's a fructan intolerance.

Dr. Will Bulsiewicz

If you take antibiotics, your risk of developing an inflammatory bowel disease in next year just doubled.

Dr. Will Bulsiewicz
60%
Microbial weight of stool Percentage of the weight of human stool that is composed of microbes (bacteria).
60,000
Microbial enzymes Approximate number of enzymes that gut microbes possess, which humans do not, used for breaking down fiber.
3 years
Microbiome development age The age by which a child's microbiome is considered fully adult-sized.
Up to 55%
Increase in IBD cases (US, 1970-2010) Increase in ulcerative colitis and Crohn's disease cases in the United States over a 40-year period.
50%
Gut barrier disruption by antibiotics Reduction in gut barrier integrity that can occur during a course of antibiotics.