Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan

Apr 3, 2026
Overview

Dr. Nathan Bryan, a leading nitric oxide researcher, reveals how common oral hygiene habits like using fluoride toothpaste and antiseptic mouthwash disrupt the oral microbiome, blocking nitric oxide production and impacting blood pressure, circulation, and exercise benefits. He also discusses the detrimental effects of sugar and antacids, and the benefits of nasal breathing and sunlight for nitric oxide.

At a Glance
13 Insights
24m 7s Duration

Deep Dive Analysis

1. Eliminate Fluoride Toothpaste

Avoid fluoride toothpaste as it has no benefit and carries significant risks, including lowering IQ, shutting down thyroid function, and acting as a neurotoxin. Opt for non-fluorinated toothpaste instead to protect your health.

2. Stop Antiseptic Mouthwash Use

Discontinue using antiseptic mouthwash because it kills the oral microbiome responsible for nitric oxide production, negating the cardiovascular benefits of exercise and contributing to high blood pressure.

3. Avoid Sugar and High Glycemic Foods

Eliminate sugar and high glycemic index foods from your diet as sugar is a “poison” that sticks to and deactivates the enzyme responsible for nitric oxide production, leading to numerous health issues like increased risk of heart attack and stroke.

4. Prioritize Nasal Breathing

Practice deep, nasal breathing to activate the enzyme in your sinuses that produces nitric oxide, which dilates bronchioles and pulmonary arteries, improving oxygen uptake, oxygen delivery, and lowering blood pressure.

5. Cease Proton Pump Inhibitor Antacids

Avoid prescription and over-the-counter proton pump inhibitors (PPIs) like Prilosec or Nexium, as inhibiting stomach acid production impairs protein breakdown and the absorption of essential micronutrients like B vitamins, magnesium, and iron.

6. Incorporate Tongue Scraping

Practice tongue scraping regularly to promote a more diverse oral microbiome and better oral health by “tilling the soil” of the tongue. However, never combine tongue scraping with antiseptic mouthwash, as this can worsen the killing of beneficial bacteria.

7. Get Daily Sunlight Exposure

Aim for 20-30 minutes of daily sunlight exposure, as both UV and full-spectrum infrared light stimulate nitric oxide release from the skin. This can improve energy production and lower blood pressure.

8. Avoid Aluminum-Containing Products

Do not use any products, including antacids like Gaviscon, that contain aluminum, as aluminum should be absolutely avoided due to its harmful effects on the body.

9. Maintain a Balanced, Moderate Diet

Consume a balanced diet in moderation, focusing on good, high-quality protein and fats with little to no carbohydrates, to support overall health and nitric oxide production.

10. Hum for Nitric Oxide Production

Experiment with humming, as certain frequencies can activate the nitric oxide synthase enzyme in your sinuses, leading to nitric oxide production. The effectiveness depends on the function of your enzyme and the volume of your nasal sinuses.

11. Request Fluoride-Free Dental Cleanings

When visiting a dental hygienist for routine cleanings, ensure they do not perform a fluoride rinse on you, as fluoride is detrimental to nitric oxide production and overall health.

12. Consider Red Light Therapy

Explore using red light beds or infrared saunas with red lights daily, as these light therapies can stimulate nitric oxide production, mitochondrial biogenesis, and improve energy production.

13. Mouth Taping with Caution

If considering mouth taping to encourage nasal breathing, first consult with a dentist for imaging to ensure your airway is open and not obstructed. This is crucial to prevent suffocation risks if forced to breathe through your nose.