#063 Dr. Roger Seheult from MedCram on COVID-19 Vaccines, Vitamin D, and Heat Hydrotherapy

Feb 26, 2021 Episode Page ↗
Overview

Dr. Roger Seheult, a quadruple board-certified physician and co-founder of MedCram Videos, discusses supporting the immune system against COVID-19. He covers the critical role of vitamin D, optimal sleep practices, and historical hydrotherapy techniques to enhance early interferon response and mitigate severe disease outcomes.

At a Glance
20 Insights
2h 6m Duration
19 Topics
6 Concepts

Deep Dive Analysis

Introduction to Dr. Roger Seheult and MedCram Videos

Challenges of Evidence-Based Treatment During a Pandemic

COVID-19 Disease Phases and Tailored Interventions

Historical Lessons from the 1918 Spanish Flu

Importance of Ventilation and Mask-Wearing

Vitamin D: A Steroid Hormone with Immune Functions

Observational and Genetic Evidence Linking Vitamin D to COVID-19

Vitamin D's Role in ACE2 and Renin-Angiotensin System

Clinical Trial Findings on Vitamin D Supplementation

Addressing Widespread Vitamin D Deficiency

Safety and Dosing of Vitamin D Supplementation

Critical Role of Sleep in Immune Function

Practical Strategies for Optimizing Sleep Quality

Hydrotherapy and Heat Stress for Innate Immunity

Spanish Flu Era Hydrotherapy Protocol and Outcomes

Current Research on Hot Hydrotherapy for Immunity

Understanding mRNA and Adenovirus COVID-19 Vaccines

Vaccine Safety, Efficacy, and Long-Term Considerations

Dr. Seheult's Personal Health Practices

Vitamin D as a Hormone

Vitamin D's chemical structure is similar to steroid hormones like cortisol and estrogen, allowing it to directly enter the cell nucleus and influence the transcription of over 5% of the human genome, making its function more akin to a hormone than a traditional vitamin.

Mendelian Randomization Studies

This type of study helps establish causation by examining genetic variations (SNPs) known to affect a factor, such as vitamin D levels, and correlating these genetic predispositions with health outcomes. This method helps to overcome confounding factors often present in observational studies.

ACE2 Receptor and Renin-Angiotensin System

The ACE2 receptor is the entry point for SARS-CoV-2 into human cells. Viral binding and internalization of ACE2 can lead to its downregulation, which is detrimental as ACE2 plays a crucial role in regulating blood pressure, fluid balance, and preventing lung injury and oxidative stress, a process vitamin D may influence.

Innate Immune System

This is the body's first line of defense, acting as a 'garbage collector' that rapidly identifies and eliminates pathogens using tools like fever and interferon. It is typically robust in children but diminishes in efficacy with age, and SARS-CoV-2 can suppress its early response.

Interferon Response

A critical early immune response against viral infections, including SARS-CoV-2, involving various types of interferon. A robust interferon response early in the disease course is associated with mild to moderate COVID-19 outcomes, while its suppression or inactivation by autoantibodies can lead to severe disease.

mRNA Vaccines

These vaccines deliver a temporary genetic message (mRNA) to cells, instructing them to produce a specific viral protein (e.g., the spike protein). This process trains the immune system to recognize and fight the virus without introducing a live virus, altering the cell's DNA, or persisting in the body long-term.

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Why is timing crucial in treating COVID-19?

COVID-19 has distinct early and late phases, typically demarcated by the onset of pneumonia. Early interventions focus on antiviral action (e.g., remdesivir), while later interventions target inflammation (e.g., steroids like dexamethasone).

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What is the optimal blood level of vitamin D for preventing SARS-CoV-2 infection?

A study of 191,000 people found that SARS-CoV-2 positivity rates increased significantly when 25-hydroxyvitamin D levels dropped below 50 nanograms per milliliter, regardless of age, race, gender, or geography.

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Why are daily or weekly vitamin D doses potentially more effective than monthly boluses for respiratory infections?

Meta-analyses of previous studies on respiratory tract infections showed that daily or weekly vitamin D supplementation was effective, but monthly doses were not, suggesting that consistent, regular intake is important for immune benefits.

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Why is sleep so important for immune function, especially against viruses?

Adequate sleep (7+ hours) significantly reduces the risk of viral infections like the common cold by 5-7 fold and improves vaccine antibody responses. Sleep deprivation increases cortisol, which impairs immune cell stickiness and overall immune function.

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What is the most important part of the night for sleep quality?

The sleep obtained before midnight, particularly slow-wave sleep, is considered the most restorative and is associated with growth hormone secretion, making it crucial for overall health and immune function.

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How does heat stress (like from saunas or hot baths) potentially boost immunity against viruses?

Heat stress can elevate core body temperature, which has been shown to increase the secretion of interferon and other immune factors tenfold, thereby enhancing the innate immune system's ability to fight off viral infections early on.

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What lessons can be learned from the 1918 Spanish Flu pandemic regarding treatment?

During the Spanish Flu, treating fever with aspirin in army hospitals led to high pneumonia rates (16%), while sanitariums using hydrotherapy (heat, fresh air, rest) saw only 2% pneumonia rates, suggesting that supporting the body's natural fever response early was beneficial.

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How do mRNA vaccines work?

mRNA vaccines deliver a temporary genetic message to cells, instructing them to produce a specific viral protein (e.g., the spike protein). This process trains the immune system to recognize and fight the virus without introducing a live virus, altering the cell's DNA, or persisting in the body long-term.

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Are there long-term side effects to worry about with new vaccines?

While rare long-term effects can occur (e.g., narcolepsy with a past flu vaccine), most vaccine side effects appear within the first 1-2 months. The risk of post-infective autoimmune conditions is generally higher from a natural COVID-19 infection than from the vaccine.

1. Follow Comprehensive CDC Guidelines

Adhere to all CDC recommendations, including mask-wearing, social distancing, hand washing, and ventilation, as a multi-faceted approach to prevent COVID-19, recognizing that no single measure is 100% effective alone.

2. Test & Supplement Vitamin D

Consult a doctor to measure your 25-hydroxyvitamin D levels and take a supplement as advised to reach sufficient levels (e.g., above 50 ng/mL), given widespread deficiency and its immune role.

3. Prioritize Sufficient Sleep

Ensure adequate sleep as it is fundamentally important for immune function and resisting viral infections, with sleep deprivation known to impair viral immunity.

4. Perform Hot Hydrotherapy Protocol

Implement a hot hydrotherapy protocol by applying very hot wet towels to the back and chest for 20 minutes while keeping the head and neck cold, followed by ice-cold towel friction rubs and one hour of rest, aiming to increase core body temperature and stimulate the innate immune system.

5. Optimize Vitamin D Dosing

When supplementing vitamin D, daily or weekly doses are likely more effective for correcting deficiencies and preventing acute respiratory tract infections than a single large monthly bolus.

6. Morning Bright Light Exposure

Get 30 minutes of bright light exposure in the morning, ideally by stepping outside, to help set your circadian clock earlier and promote better sleep at night.

7. Minimize Evening Blue Light

Reduce blue light exposure in the evening to avoid disrupting melatonin production and delaying your circadian rhythm, using dimmers or red-light settings on smart lights.

8. Prioritize Pre-Midnight Sleep

Aim to get significant sleep before midnight, as the early part of the night is rich in restorative slow-wave sleep, which is crucial for growth hormone secretion and overall health.

9. Sleep Well Before Vaccination

Ensure you get a good night’s sleep before receiving a vaccination, as sufficient sleep can lead to a better immune response with higher antibody titers.

10. Practice Hot-Cold Contrast Therapy

Engage in contrast therapy by alternating between hot (e.g., spa, sauna) and cold (e.g., snow, cold shower) exposures, as this practice is invigorating and may stimulate the immune system.

11. Take Contrast Showers

Incorporate contrast showers into your routine by alternating between hot (3-5 minutes, as tolerated) and cold (1 minute, as tolerated) water cycles, repeating several times, to invigorate and potentially support immune function.

12. Improve Indoor Ventilation

Enhance ventilation in enclosed spaces, especially when with others, by cracking windows or using air filters, to significantly reduce the risk of airborne COVID-19 transmission.

13. Implement Home Decontamination Routine

Establish a routine upon returning home from high-exposure environments, such as immediately disrobing in a designated area (e.g., garage) and isolating potentially contaminated clothing for washing.

14. Hydrotherapy Safety Precautions

Exercise extreme caution with hydrotherapy to prevent burns and avoid temperature extremes if you have a history of cardiac arrhythmias (tachycardia, atrial fibrillation), as these conditions may pose risks.

15. Eat Antioxidant-Rich Fruits

Consume a variety of antioxidant-rich fruits like blackberries, strawberries, raspberries, and pineapple, ideally for breakfast, to support overall health and provide beneficial compounds.

16. Consider NAC Supplementation

Consider supplementing with N-acetylcysteine (NAC) as a powerful antioxidant that has shown to improve flu symptoms and may help with oxidative stress, though its specific effect on COVID-19 is not yet established.

17. Supplement Zinc (Max 40mg)

Supplement with elemental zinc, but strictly limit daily intake to no more than 40 milligrams to avoid potential adverse effects such as copper imbalance.

18. Avoid Evening Emotional Stimulation

Refrain from emotionally stimulating activities, such as engaging with work on a laptop or checking social media, before bed, as they can elevate stress and significantly disrupt sleep quality.

19. Decompress Before Bed

Prioritize relaxing activities like reading a book or simply decompressing in a quiet environment before bed, rather than watching stimulating TV, to promote mental calm and better sleep.

20. Cultivate Grounding & Faith

Develop a sense of grounding and place faith in something higher than oneself to effectively cope with stress, illness, and the challenges of life, beyond just physical interventions.

If you want to try to save lives... what we have to do is marry those two concepts together and come up with things, I believe, that may have plausibility to work. But if we're going to institute something, if we're going to do something, it's got to have very, very low risk.

Dr. Roger Seheult

Vitamin D is not just a vitamin. It literally falls more into hormonal.

Dr. Roger Seheult

It's not an, or it's an, and it's an, all of the above type of thing. And just because you supplement doesn't mean you shouldn't go on the sun, just because you go in the sun doesn't mean you shouldn't supplement.

Dr. Roger Seheult

The most important time to sleep is really that time before midnight... two hours of sleep before midnight is worth more than four hours of sleep after midnight.

Dr. Roger Seheult

Here we are in this pandemic, and we don't have all the medications to treat all these patients. Instead of saying, you know what, you're just going to have to wait at home and wait for you to be sick enough to go to the hospital, that's kind of like turning back the clock thousands of years. Why don't we just turn back the clock a hundred years and see what we did a hundred years ago when we didn't have these things and see if they work.

Dr. Roger Seheult

Your risk of getting a post-infective autoimmune condition is probably higher in COVID, if you were to get infected with COVID versus getting the vaccine.

Dr. Roger Seheult

Hot Hydrotherapy for Immune Enhancement (Spanish Flu Era / Current Research)

Dr. Roger Seheult
  1. Have the patient lie down on a surface.
  2. Place very hot, wet towels (sandwiched between other towels) on the patient's back and chest.
  3. Place a very cold towel on the patient's head and neck.
  4. Maintain the heat for approximately 20 minutes, recycling towels as needed to keep them hot, aiming to induce sweating and elevate core body temperature.
  5. After 20 minutes, replace the hot towels with ice-cold towels and perform a friction rub to cause vasoconstriction, lock in heat, and demarginate leukocytes.
  6. Ensure the patient rests for one hour without movement after the treatment.

Dr. Seheult's Personal Daily Health Practices

Dr. Roger Seheult
  1. Ensure adequate sleep.
  2. Perform contrast showers (e.g., 3-5 minutes hot, 1 minute cold, repeated, as tolerated).
  3. Supplement with vitamin D.
  4. Consume a large bowl of antioxidant fruits for breakfast (e.g., blackberries, strawberries, raspberries, pineapple).
  5. Take NAC (N-acetylcysteine) and zinc (not exceeding 40 milligrams of elemental zinc per day).
50%
Decrease in acute chest infections with vitamin D supplementation Reported in a British Medical Journal meta-analysis
70%
US population categorized as vitamin D insufficient (<30 ng/mL) According to the Endocrine Society definition
30%
US population categorized as vitamin D deficient (<20 ng/mL) According to the Endocrine Society definition
30 times
African Americans more likely to be vitamin D deficient than Caucasians Based on NHANES data
6 times
Longer time African Americans in Chicago need to spend in sun to make same vitamin D as Caucasians Due to melanin acting as natural sunscreen and geographical location
4,000 IUs/day
Upper tolerable intake level for vitamin D Set by the Institute of Medicine
10,000 IUs/day
Vitamin D dose in a long-term supplementation study with no toxic effects Specific duration not recalled, but noted as long-term
4.8 to 5 nanograms per milliliter
Approximate increase in 25-hydroxyvitamin D levels for every first 1,000 IUs of supplementation Non-linear response curve, increments decrease at higher doses
2%
Patients going to ICU in Spanish calcifediol study (calcifediol group) Compared to 50% in the placebo group; study had some randomization issues
80,000 IUs
Vitamin D dose given every three months to nursing home patients in France Showed benefit if given within 30 days of COVID-19 admission
60,000 units/day for 7 days
Vitamin D supplementation regimen for hospitalized COVID-19 patients in SHADE study (India) Resulted in improved COVID-19 negative test rates and lower fibrinogen by day 21
5 to 7 fold
Difference in risk of getting a common cold (rhinovirus) for those getting less than 7 hours of sleep vs. more Observed in a study where subjects were exposed to rhinovirus
10 times higher
Increase in interferon levels in monocytes exposed to LPS at fever temperature (39°C) Compared to lower temperatures
14%
Percentage of severe COVID-19 cases linked to genetic mutations affecting interferon production Found in a Science paper cohort study
10%
Percentage of severe COVID-19 cases linked to autoantibodies against interferon in older patients Found in a Science paper cohort study
80%
Percentage of symptomatic COVID-19 patients who never need hospitalization Due to effective innate immune response
2%
Pneumonia development in Spanish Flu patients in sanitariums (hydrotherapy) Compared to 16% in army hospitals (aspirin)
1.1%
Infection fatality rate in Spanish Flu sanitariums Compared to 6.4% in army camps
20%
Lower pneumonia risk for men using sauna 2-3 times a week Dose-dependent, up to 40% for 4-7 times/week, from observational studies
60%
COVID-19 patients still showing myocarditis one month after infection Reported in a study on long-term effects