#098 How to Train According to the Experts
Dr. Rhonda Patrick and exercise science communicator Brady Holmer deconstruct evidence-based exercise protocols for enhancing muscle strength and cardiovascular health. They discuss optimal training zones, HIIT, resistance training, and supplements for longevity and vitality, drawing insights from leading experts.
Deep Dive Analysis
21 Topic Outline
Defining Training Goals and Cardiorespiratory Fitness
Measuring VO2 Max and its Longevity Implications
Understanding Training Zones and Intensity Metrics
Benefits of Zone 2 Training and HIIT for Fitness
Adjusting the 80/20 Rule for Time-Efficient Training
Evidence-Based High-Intensity Interval Training Protocols
Age-Related Heart Stiffness and Exercise Dose for Reversal
Dr. Benjamin Levine's Exercise Prescription for Life
Hosts' Personal Exercise Routines and Training Philosophy
Mitochondrial Health: HIIT vs. Zone 2 for Fat Burning
Exercise Intensity and Glucose Regulation Benefits
Training for Brain Health and BDNF Production
Exercise Snacks: Short Bursts of Activity for Health
Age-Related Decline in Muscle Mass, Strength, and Power
General Principles for Effective Resistance Training
Optimizing Strength and Hypertrophy Training
Resistance Training for Body Recomposition
Time-Efficient Resistance Training Protocols
Sauna Use for Cardiorespiratory Fitness and Muscle Health
Protein Intake and Distribution for Muscle Growth
Creatine Supplementation: Benefits and Best Practices
5 Key Concepts
Cardiorespiratory Fitness (VO2 Max)
This is the exercise physiologist's measure of aerobic fitness, representing the body's integrative ability to take in, distribute, and utilize oxygen for energy. It's a potent predictor of longevity and is typically measured during maximal exercise to exhaustion.
Powerpenia
This term refers to the age-related loss of muscle power, which is the ability to generate force quickly (e.g., standing up from a chair rapidly). It declines earlier and more rapidly than muscle mass or strength, making it a sensitive indicator of functional outcomes with age.
Reps in Reserve (RIR)
This concept in resistance training refers to how many additional repetitions you could perform before reaching complete muscular failure. Training with one to three reps in reserve appears to be as effective as training to failure for maximizing strength and hypertrophy, while potentially reducing injury risk.
Anabolic Barn Door
This is a metaphor used to describe the 'anabolic window' for protein consumption after resistance training. Instead of a narrow 30-minute window, it's a much larger 'barn door' meaning you don't need to consume protein immediately after a workout to optimize gains, as long as total daily protein intake is sufficient.
Vigorous Intermittent Lifestyle Physical Activity (VILPA)
These are unstructured, short bursts of vigorous physical activity integrated into daily life, such as sprinting up stairs or briskly walking. Studies show that even 1-2 minute bouts, three times a day, can significantly reduce all-cause, cardiovascular, and cancer-related mortality, even in non-exercisers.
13 Questions Answered
Cardiorespiratory fitness, often referred to as VO2 max, is the body's ability to take in, distribute, and utilize oxygen. It's typically measured in a lab during maximal exercise to exhaustion, but can be estimated using tests like the Cooper 12-minute run or smartwatches.
Yes, studies like the Dallas Bed Rest Study showed that three weeks of extreme bed rest resulted in a decline in cardiorespiratory fitness comparable to 30 years of aging, highlighting the profound negative impact of prolonged sedentary behavior.
Training zones can be defined by rating of perceived exertion (RPE), the talk test, or percentage of maximal heart rate. Zone 1 (recovery) allows full conversation, Zone 2 (light-moderate) allows conversation but with effort, Zone 3 (threshold) allows broken sentences, Zone 4 (high intensity) allows only 1-2 words, and Zone 5 (maximal) allows no talking.
The 80/20 rule (80% low-moderate intensity, 20% high intensity) is based on elite athlete training logs and works well for high-volume exercisers (8+ hours/week). For those exercising less (1-4 hours/week), a 70/30 or 60/40 split with more high-intensity training may be more beneficial and time-efficient.
Observational studies suggest that exercising four to five days per week appears to be the optimal frequency across the lifespan to prevent cardiovascular aging and maintain youthful heart structure, which is more than the commonly recommended 150 minutes per week.
Yes, a two-year intervention study in sedentary 50-year-olds showed that a structured exercise protocol (5-6 hours/week including HIIT, long base pace, and resistance training) reversed 20 years of cardiac aging, improving heart compliance and size to resemble that of healthy 30-year-olds.
While Zone 2 training maximizes fat oxidation *during* exercise, high-intensity interval training (HIIT), when volume-matched, appears to be as good or better at enhancing overall fat oxidation capacity by increasing mitochondrial content and CPT enzyme levels, which are crucial for fat metabolism.
Higher intensity exercise, like HIIT, leads to greater improvements in glucose regulation compared to continuous moderate intensity exercise, even when volume-matched. This is partly due to increased lactate production and more robust muscle engagement, which stimulates glucose transporter translocation to muscle cell surfaces.
Exercise snacks are short bursts of vigorous physical activity (1-10 minutes, structured or unstructured) done intermittently throughout the day. They can improve VO2 max, cardiometabolic health (blood pressure, glucose), reduce all-cause and cancer mortality, break up sedentary time, and offer psychological benefits like increased focus.
No, training to muscular failure is not necessary to optimize strength or hypertrophy. Training with one to three 'reps in reserve' (stopping a few reps before failure) appears to be equally effective, while also reducing injury risk and improving recovery for subsequent sessions.
No, strength training cannot replace aerobic exercise for cardiovascular health. While heart rate elevates during strength training, this is primarily due to central nervous system drive, not increased metabolic demand for blood flow like in aerobic exercise. Therefore, strength training does not provide the same cardiac adaptations as cardio.
Engaging in resistance training two times per week for 30 minutes per session appears to be the bare minimum to maintain or even build muscle strength and hypertrophy. Optimal benefits are often seen with three times per week, with higher frequencies for performance-oriented athletes.
Yes, combining sauna use with exercise can further improve cardiorespiratory fitness, blood pressure, and cholesterol levels. Regular sauna use (2-7 times/week) is associated with significant reductions in cardiovascular and all-cause mortality, and may support muscle hypertrophy and reduce disuse atrophy.
57 Actionable Insights
1. Define Training Goals
Before starting any training, identify your specific goals, such as becoming an elite athlete, improving health span, reducing disease risk, or maintaining independence with age, as this will determine how you should train.
2. Integrate Exercise as Hygiene
Adopt a mindset where exercise is considered an essential part of your daily personal hygiene, like brushing your teeth, making it a non-negotiable activity rather than a choice.
3. Apply Resistance Training Principles
Adhere to fundamental resistance training principles: prioritize consistency with an enjoyable regimen, implement progressive overload by gradually increasing challenge, ensure adequate recovery (including sleep and nutrition), and focus on consistent execution over perfection.
4. Follow Levine’s Exercise Prescription
Adopt Dr. Levine’s “Prescription for Life” by aiming for 5-6 hours of total training per week, including one HIIT session, a light recovery day after HIIT, one hour-plus base pace session, another 30-minute base pace session, and two or more resistance training sessions weekly, scaling up gradually.
5. Exercise 4-5 Days/Week for Heart
Aim for four to five days per week of aerobic exercise throughout your lifespan to achieve optimal protection against cardiovascular aging and maintain youthful heart structure.
6. Prioritize Heart Health Before 70
Focus on improving and maintaining the youthful structure of your heart through consistent exercise before age 70, as reversing structural changes becomes nearly impossible after this point.
7. Optimize Daily Protein Intake
Increase your daily protein intake to at least 1.6 grams per kilogram of body weight (or 2.2 g/kg for muscle gain) to support muscle mass and strength, distributing 25-30+ grams across 3-4 evenly spaced meals, while understanding that immediate post-workout timing is less critical than total daily intake.
8. Supplement with Creatine Monohydrate
Supplement with 5-10 grams of creatine monohydrate daily, without needing a loading phase, to enhance muscle performance, strength, and mass, and potentially benefit brain function, as it is a safe and well-studied supplement.
9. Combine Strength and Endurance
Integrate both strength training and endurance exercise into your routine, as each provides distinct and crucial physiological benefits that the other cannot fully replicate.
10. Prioritize Multi-Joint Exercises
For optimal strength improvement, bone density, and time efficiency, prioritize multi-joint (compound) exercises such as squats, deadlifts, lunges, rows, and presses, as they engage multiple muscle groups and joints simultaneously.
11. Optimize for Body Recomposition
To achieve body recomposition (losing fat while gaining muscle), consistently engage in resistance training (ideally 3x/week), maintain a conservative caloric deficit (10-20% below maintenance), consume high protein (2.2g/kg body weight), and prioritize adequate sleep.
12. Integrate Sauna for Health & Performance
Incorporate deliberate heat exposure (sauna) 2-7 times per week for 20 minutes at ~175°F, ideally immediately after exercise, to enhance cardiorespiratory fitness, endurance, recovery, and reduce mortality risks.
13. Avoid Cold After Resistance Training
Do not engage in deliberate cold exposure, such as a cold bath, immediately after resistance training, as it can blunt muscle protein synthesis and compromise hypertrophic gains.
14. Increase Exercise with Age
Consider increasing your exercise frequency and duration as you get older, especially in middle and later life, to maintain cardiovascular structure and other health benefits, leveraging potentially increased free time.
15. Integrate Exercise Snacks (VILPA)
Incorporate short bursts of vigorous intermittent lifestyle physical activity (VILPA) or structured exercise snacks (1-10 minutes, 80%+ max heart rate) throughout your day to break sedentary time, improve cardiometabolic health, boost cognition, and significantly reduce mortality risks.
16. Short HIIT Boosts Cognition
Engage in short high-intensity interval training (HIIT) workouts, even as brief as 10 minutes, to acutely improve cognition and enhance brain-derived neurotrophic factor (BDNF) levels.
17. HIIT for Glucose Regulation
Incorporate high-intensity interval training (HIIT) into your routine to significantly improve glucose regulation, as it promotes the translocation of glucose transporters to muscle cell surfaces.
18. Utilize Training Zones
Guide your exercise intensity using a combination of Rating of Perceived Exertion (RPE), the talk test, and percentage of maximal heart rate to target specific physiological adaptations from recovery (Zone 1) to maximal effort (Zone 5).
19. Apply Progressive Stress
Continuously stress your cardiovascular system by adding additional challenges or stimuli to your workouts to ensure ongoing beneficial adaptations and avoid stagnation in improvement.
20. Incorporate High-Intensity Training
To continuously improve fitness and overcome plateaus, add high-intensity interval training (HIIT) to your routine at least once a week to provide a greater stimulus for adaptation.
21. Time-Efficient HIIT for Volume
If you are time-limited and your total weekly exercise volume is low (e.g., 1-4 hours), consider skewing your training towards more high-intensity interval training (HIIT) to achieve similar benefits to higher volumes of moderate intensity exercise.
22. Combine Moderate & High Intensity
Combine moderate-intensity exercise (like a Zone 2 run or ride) with high-intensity intervals in the same session, using the moderate intensity as a warm-up, to optimize benefits and manage time efficiently.
23. Vary HIIT Interval Lengths
To stress your system in different ways and avoid stagnation or boredom, vary the length of your high-intensity intervals each week, for example, rotating between 4-minute, 1-minute, and 20-second protocols.
24. Implement Specific HIIT Protocols
Utilize evidence-based high-intensity interval training (HIIT) protocols like the Norwegian 4x4, 10x1, or Tabata to improve cardiorespiratory fitness, mitochondrial density, and metabolic benefits.
25. Train for Hypertrophy (Muscle Growth)
To increase muscle size (hypertrophy), lift weights at 60-80% of your one-repetition maximum for 6-12 repetitions per set, with shorter rest periods of 1-2 minutes between sets, prioritizing multi-joint exercises and those targeting desired muscle groups.
26. Strength Train with Heavy Weight
For strength training, lift heavy weights, aiming for 85% or more of your one-repetition maximum (1RM), which typically involves fewer repetitions per set.
27. Allow Ample Rest for Strength
When strength training with heavy weights, allow for two to five minutes of rest between sets to ensure adequate recovery of phosphocreatine stores and the nervous system, enabling maximal effort for subsequent sets.
28. Train with Reps in Reserve
Optimize strength and hypertrophy by training with one to three “reps in reserve” (RIR), meaning stopping a set when you could still perform 1-3 more repetitions, as this is as effective as training to failure without the added risks.
29. Experience Training to Failure
Train to complete muscular failure at least once per training block to understand what true failure feels like, which will help you more accurately gauge “reps in reserve” in subsequent workouts.
30. Train to Failure on Machines
If choosing to train to failure, do so primarily with machine-based exercises or single-joint movements (e.g., bicep curls) to minimize injury risk compared to free weights or multi-joint exercises.
31. Strength Training is Not Cardio
Understand that while strength training elevates heart rate, it does not provide the same cardiovascular adaptations as aerobic exercise, so it cannot replace dedicated cardio sessions for heart health.
32. Prioritize Muscle Group Training
When structuring your hypertrophy workout, train the muscle groups you want to grow first, as they will receive the most focus and energy when you are freshest.
33. Increase Muscle for Fall Risk
Focus on increasing overall muscle strength and mass through resistance training, regardless of specific exercise type (e.g., barbell squats vs. hack squats), to effectively reduce your risk of falls and improve functional independence with age.
34. Time-Efficient Resistance Training
Maximize efficiency in resistance training by prioritizing multi-joint exercises, incorporating supersets (back-to-back exercises without rest) and drop sets (reducing load and increasing volume), combining strength and hypertrophy within sessions, and using progressive loading as a dynamic warm-up.
35. Utilize Micro Resistance Workouts
If time-limited, perform micro resistance training workouts (e.g., 15 minutes, 6-8 times per week) to achieve similar strength and hypertrophy gains as longer, less frequent sessions, by delegating different exercises to different days.
36. Order Training by Primary Goal
When combining cardio and strength training on the same day, order your sessions based on your primary goal: perform your priority training (e.g., long run for endurance, heavy lifting for strength) first to ensure optimal performance and quality for that session.
37. Minimum Resistance Training Dose
Engage in resistance training at least two times per week for 30 minutes per session to maintain or even build muscle strength, making the most of that time with efficient protocols.
38. Supplement with Omega-3 Fatty Acids
Supplement with omega-3 fatty acids, potentially at higher doses (e.g., 3-5 grams/day), to aid in recovery, reduce inflammation, prevent disuse atrophy during periods of inactivity, and support cardiovascular health.
39. Maintain Glucose Regulation
Prioritize maintaining and improving glucose regulation throughout your life to prevent the stiffening of heart tissues and blood vessels, which can lead to lower cardiac compliance and affect cardiovascular health.
40. Break Sedentary Time with Squats
To improve glucose clearance, break up sedentary periods by performing 10 bodyweight squats every 45 minutes throughout an 8-hour workday, which has been shown to be more potent than a continuous 30-minute walk.
41. Use Interval Walking for Glucose
Improve 24-hour glucose regulation and cardiometabolic risk factors by incorporating interval walking, alternating between higher (75%) and lower (60%) intensities, even if not full high-intensity training.
42. Exercise Snacks Around Meals
Perform short exercise snacks, such as bodyweight squats or burpees, around meal times to improve glucose regulation, particularly beneficial for individuals with metabolic dysfunction or when consuming less disciplined diets.
43. Use Snacks to Meet Activity Minimums
If your main training sessions don’t meet minimum recommended physical activity levels, use exercise snacks as an additive strategy to increase total weekly exercise volume and ensure you hit health targets.
44. Invest in a Chest Strap HR Monitor
For more accurate heart rate data during exercise, invest in a chest strap monitor, as smartwatches can become less accurate at higher intensities, and it’s a relatively inexpensive investment.
45. Beginners Use Talk Test for Intensity
If you are new to exercise, use the talk test to gauge your intensity, as accurately assessing Rating of Perceived Exertion (RPE) requires more experience and understanding of maximal effort.
46. Combine Intensity Metrics
For comprehensive and reliable assessment of exercise intensity, use a combination of heart rate, Rating of Perceived Exertion (RPE), and the talk test, noting how they correlate during your workout.
47. Improve Lactate Clearance
Enhance your body’s ability to clear lactate by incorporating high-intensity interval training (HIIT), steady-state or lactate threshold workouts, and Zone 2 training into your routine.
48. Finish Runs with Sprints
Incorporate very hard sprints or an uptempo pace during the last portion of your run to elevate heart rate and potentially gain additional physiological and cognitive benefits.
49. Use 10-Minute HIIT for Focus
Perform a short 10-minute high-intensity interval training (HIIT) workout, such as a Tabata, before tasks requiring sharpness or focus to experience an acute cognitive boost.
50. Optimize BDNF with Intensity & Volume
To robustly increase brain-derived neurotrophic factor (BDNF), prioritize both intensity (at least 80% max heart rate for 20 minutes) and volume (doubling to 40 minutes for even greater increases) in your workouts.
51. Tackle Hardest Task First
Address your most mentally challenging task, such as strength training, first thing in the morning, as successfully completing it can make subsequent daily tasks feel significantly easier.
52. Avoid PRs Under High Stress
If you are experiencing high psychological stress, postpone attempts at personal records (PRs) in weightlifting, as stress can increase injury risk and compromise performance.
53. Track Caloric Intake for Deficit
To effectively create a caloric deficit for fat loss, track your daily caloric intake for a few days to establish an average baseline before determining how much to reduce.
54. Use Lean Protein Sources
When increasing protein intake for body recomposition, opt for lean protein sources or protein powders to boost protein without adding excessive calories or fat.
55. Choose Enjoyable Exercise
Select enjoyable activities for your longer exercise sessions, such as hiking or dancing, to ensure sustainability and adherence to your “prescription for life” training regimen.
56. Leverage Accountability for Consistency
Enhance consistency in your exercise routine by working with a coach, joining group classes, or exercising with friends to leverage accountability and the fun social aspect.
57. Focus Beyond VO2 Max
Understand that you can still improve speed, strength, and overall exercise performance even if your VO2 max doesn’t show improvement, as other factors like lactate threshold and exercise economy contribute to fitness.
5 Key Quotes
Exercise needs to be part of your personal hygiene. It's like brushing your teeth. You wake up, you know, it's not something that you think, oh, should I do this? It's I'm going to wake up and I'm going to do this because it's part of your personal hygiene.
Dr. Benjamin Levine
Essentially, three weeks of bed rest is worse for your cardiovascular health, for your cardiorespiratory fitness, than 30 years of aging.
Rhonda Patrick
The most effective training regimen is the one that you're going to follow.
Dr. Lane Norton
You actually get stronger when you aren't exercising, not when you are.
Dr. Lane Norton
If you're doing high intensity interval training, you're just, you're just burning glucose and, and producing lactate. And that's just not the case. In fact, the majority of the time, even when you're doing a high intensity interval training workout, you're doing both.
Rhonda Patrick
5 Protocols
Norwegian 4x4 High-Intensity Interval Training
Dr. Martin Gabala, Dr. Benjamin Levine- Perform four minutes of vigorous exercise at an intensity that can be sustained for the entire duration (not maximal, but very hard).
- Follow with a three-minute period of very light, active recovery to allow heart rate to come down and lactate to clear.
- Repeat this interval sequence four times.
10x1 High-Intensity Interval Training
Dr. Martin Gabala- Perform one minute of vigorous exercise, going as hard as can be sustained for that minute.
- Follow with one minute of very low-intensity recovery exercise.
- Repeat this sequence 10 times.
Tabata High-Intensity Interval Training
Dr. Martin Gabala- Perform 20 seconds of all-out maximal effort exercise.
- Follow with 10 seconds of rest.
- Repeat this sequence eight times.
Dr. Benjamin Levine's Prescription for Life (2-Year Intervention)
Dr. Benjamin Levine- Gradually scale up exercise over two years to reach a total of 5-6 hours of training per week.
- Include one Norwegian 4x4 HIIT session per week (or similar interval training).
- Include one session per week of an hour or longer at a base pace (low to moderate intensity, Zone 2).
- Include another 30-minute base pace session per week (low to moderate intensity, Zone 2).
- Take a very light active recovery day after every high-intensity interval training session.
- Incorporate two resistance training sessions per week.
Exercise Snacks (VILPA) for Health Benefits
Dr. Martin Gabala- Engage in 1-2 minute bursts of vigorous physical activity (e.g., sprinting stairs, brisk walking, bodyweight squats, burpees).
- Perform these bursts three times a day.
- Integrate these activities into daily routines without special equipment or clothing changes.