Essentials: Using Play to Rewire & Improve Your Brain

Jan 29, 2026 Episode Page ↗
Overview

Andrew Huberman, a professor of neurobiology and ophthalmology at Stanford, explains how play shapes the brain across the lifespan. He details how play engages specific brain circuits and neurochemicals, enhancing cognitive flexibility and creative thinking in adults.

At a Glance
17 Insights
35m 11s Duration
13 Topics
6 Concepts

Deep Dive Analysis

The Utility and Power of Play

Brain Circuits and Neurochemistry of Play

Childhood Play and Low-Stakes Exploration

Adopting a Playful Mindset as an Adult

Universal Play Postures and Expressions

Group Play, Rule Testing, and Social Development

Role Play for Brain Expansion

Defining Effective Play for Brain Health

Play as a Portal to Neuroplasticity

Richard Feynman: A Lifelong Playful Tinkerer

Forms of Play for Enhanced Neuroplasticity

Understanding Personal Play Identity

Lifespan Development and the Persistence of Play Circuits

Periaqueductal Gray (PAG)

A brainstem area rich in neurons that release endogenous opioids like enkephalin. During play, the PAG releases small amounts of these opioids, creating a chemical state that allows the prefrontal cortex to explore different roles and contingencies.

Endogenous Opioids

Biologically made opioids released by neurons in the periaqueductal gray during play. Their release into the brain helps relax the system and enables the prefrontal cortex to expand its operational capacity, fostering exploration in low-stakes environments.

Low-Stakes Environment

A crucial condition for effective play, where individuals feel comfortable exploring different outcomes and assuming various roles without high levels of stress or concern about the consequences. This environment facilitates the release of endogenous opioids and supports prefrontal cortex flexibility.

Play Postures

Universal non-verbal cues, seen in both animals and humans, that signal an intent to play. Examples include a dog's head-lowering 'play bow' or a human's subtle head tilt with open, 'soft eyes' and slightly pursed lips, indicating a non-aggressive, playful disposition.

Neuroplasticity

The brain's ability to change and rewire its circuits in response to experience. Play is described as a powerful portal to neuroplasticity, especially when it involves exploring contingencies in a high opioid, low epinephrine state, which triggers the deployment of growth factors like brain-derived neurotrophic factor.

Personal Play Identity

A concept describing how individual aspects like personality, sociocultural environment, and past experiences (especially in early adolescence) shape how one engages with play and, by extension, how they interact in adult work and relationships. It influences competitiveness, cooperation, and role-taking preferences.

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What is the fundamental utility of play?

Play serves as a crucial mechanism for exploring contingencies and expanding one's catalog of potential outcomes in low-stakes environments, allowing the brain to learn and adapt without significant risk.

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How does play biologically affect the brain?

Play engages the periaqueductal gray (PAG) to release endogenous opioids, which, in concert with low adrenaline, allows the prefrontal cortex to become more plastic and explore different roles and possibilities, enhancing executive function.

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How can adults benefit from reintroducing play into their lives?

Adults can benefit by expanding their prefrontal cortex's capacity, increasing cognitive flexibility, fostering creativity, and enhancing neuroplasticity, which helps keep the brain 'young' and adaptable across the lifespan.

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What are the universal non-verbal signals of play?

In humans, common play postures include a subtle head tilt with open, 'soft eyes' and sometimes briefly raised eyebrows or a slight smile, signaling a non-threatening and playful intention.

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What defines 'effective' play for brain expansion and neuroplasticity?

Effective play involves engaging with some focus and seriousness in low-stakes environments, characterized by high endogenous opioid release and low levels of adrenaline, allowing for novel behaviors and interactions without stress over the outcome.

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What types of play are most effective for enhancing neuroplasticity in adults?

Activities involving novel, dynamic movements (like dance or multi-dimensional sports) and those that require adopting different roles within the activity (like chess, where different pieces have different rules) are particularly conducive to neuroplasticity.

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How does childhood play influence adult behavior and interactions?

Early adolescence (ages 10-14) is a peak time for social and motor development through play, shaping one's 'personal play identity' and influencing how individuals approach cooperation, competition, leadership, and role-switching in adult work and relationships.

1. Rethink Play as Contingency Exploration

Stop viewing play solely as a child’s or sport activity; instead, understand it as an exploration of ‘if I do A, what happens?’ to expand your catalog of potential outcomes. This perspective is key to enriching emotional, intellectual, and social lives.

2. Re-engage Play for Neuroplasticity

To engage neuroplasticity at any age, return to play, as it is the most powerful portal to plasticity, triggering brain rewiring and growth factors by mimicking natural developmental learning processes.

3. Engage in Regular Play

Adopt a playful stance and engage in play on a regular basis, focusing on low-stakes contingency exploration with attention but without high adrenaline, to benefit from ongoing neuroplasticity.

4. Play with Focus, Low Stakes

Engage in play with a degree of focus and seriousness, but ensure the stakes remain low enough to avoid high levels of adrenaline. This balance allows for the liberation of endogenous opioids, fostering a state conducive to neuroplasticity.

5. Prioritize Exploration Over Proficiency

When engaging in play, focus on exploring contingencies with truly low stakes rather than worrying about becoming good or proficient. This mindset is crucial for accessing the neurochemical states that open up neuroplasticity.

6. Adopt a Playful Mindset

Cultivate a playful mindset by allowing yourself to expand the number of outcomes you’re willing to entertain and consider how you relate to them, which benefits everyone, especially those less naturally playful. This helps open up prefrontal cortex circuits for exploring different possibilities.

7. Increase Willingness for Low-Stakes Activities

Increase your willingness to participate in low-stakes activities where you may not understand all the rules or be proficient, as this engagement provides information about yourself and others, thereby opening up prefrontal cortex circuits.

8. Play Games You’re Not Good At

Intentionally put yourself into scenarios, like playing games you’re not proficient in, where you might not be the top performer but the stakes are low. This allows for learning about yourself and others, opening up prefrontal cortex circuits.

9. Engage in Novel, Dynamic Movements

To best foster neuroplasticity, engage in play involving novel and dynamic forms of movement, including different speeds and angles, such as dance or sports like soccer, provided it’s not taken too seriously.

10. Do Dance or Multi-Dimensional Sports

Participate in activities like dance or sports (e.g., soccer) that involve dynamic, non-linear movements, jumping, and movement at different angles, as these are highly conducive to play-related neuroplasticity, especially when not taken too seriously.

11. Pick Activities with Multiple Roles

For non-physical play that expands neuroplasticity, choose activities like chess that allow you to adopt different roles and identities within the game, rather than rigidly linear ones, as this dynamically explores different thoughts and roles.

12. Expand Play to New Groups

If you already play regularly, expand your repertoire to include new forms of play, especially those involving new groups of individuals. This approach helps your brain learn, evolve, and improve.

13. Self-Reflect on Play Responses

Reflect on your past play experiences and current reactions to playful interactions, asking if you take things too seriously or overreact aggressively to playful jabbing or sarcasm. This self-assessment helps understand your social dynamics.

14. Engage in Role Play

Participate in role play, taking on different roles distinct from your natural world roles, to expand your brain’s capacity to make predictions from various standpoints and learn how to function in new ways.

15. Use Head Tilt to Signal Play

When you want to signal playfulness to others, adopt a subtle or not-so-subtle head tilt with your eyes open, as this is a universal human play posture.

16. Adopt ‘Soft Eyes’ and Lip Purse

To engage in play, open your eyelids somewhat (soft eyes) and slightly purse your lips, often combined with a head tilt and a smile. This contrasts with narrowed eyes seen in aggression or sadness.

17. Shrink Body Size Playfully

During playful interactions, unless it’s highly competitive, subtly shrink your body size rather than trying to appear larger. This is a human partial posture that signals non-aggression and willingness to play.

Play is powerful at making your prefrontal cortex more plastic, more able to change in response to experience, but not just during the period of play, but in all scenarios, because you get one prefrontal cortex.

Andrew Huberman

Play is the most powerful portal to plasticity.

Andrew Huberman

Biology does not waste resources. It's extremely efficient. And were the circuits for play not to be important in adulthood, they would have been pruned away. But I guarantee you they are there in your brain and nervous system now, they will be there tomorrow, and they will be there going forward.

Andrew Huberman

Play is really about exploring things in a way that feels safe enough to explore.

Andrew Huberman
25 years old
Approximate age when neuroplasticity mechanisms transition This is an approximate age for shifts in the underlying mechanisms of neuroplasticity, but development continues throughout life.
10 to 14 years old
Peak age range for social, motor, and psychosocial development through play This period is crucial for learning where one fits into hierarchies and developing personal play identity.