Healing From Grief & Loss | Dr. Mary-Frances O'Connor

Episode 231 Jun 2, 2025 Episode Page ↗
Overview

Dr. Mary-Frances O’Connor, a neuroscientist and clinical psychologist, discusses the science of grief, distinguishing it from grieving as a process of learning to live with loss. She explains how attachment neurobiology, dopamine, and yearning are central to grief, and offers science-supported tools to navigate the physiological and psychological challenges of loss.

At a Glance
19 Insights
2h 34m Duration
14 Topics
6 Concepts

Deep Dive Analysis

Grief vs. Grieving: Understanding the Process of Loss

Sudden vs. Anticipated Death and Attachment Biology

The Neuroscience of Yearning: Dopamine and Addiction-Like Thirst

Cultural Context of Grief and Loss of Grief Literacy

Protest, Despair, and Transmutation in the Grieving Process

Bereavement Support and the Medical Risks of Grief

Navigating Grief: Emotions, Body, and Coping Tools

Revisiting Grief Stages: Beyond Linear Progression

Grieving Suicide: Rumination and Finding a Path Forward

Belief Systems, Religion, and the Afterlife in Grief

Contemplating Death as a Tool for Living and Empathy

Mental Oscillation and the Dual Process Model of Bereavement

Avoidance, Resilience, and Seeking Professional Help

Time Perception and End-of-Life Experiences

Grief vs. Grieving

Grief refers to the immediate, in-the-moment emotional, physical, and mental reaction to loss. Grieving, on the other hand, is the ongoing process of how grief changes over time, representing the learning curve of adapting to life with the absence of the loved one.

Attachment Neurobiology in Grief

When a deep bond is formed, the brain creates an implicit, everlasting belief in the presence of the loved one. In death, the brain struggles with the conflict between knowing the person is physically gone and this ingrained belief that they are still 'out there,' which is a core driver of grief waves.

Yearning and Dopamine

Yearning, or pining for a lost loved one, is a central feature of grief, mediated by the dopamine system, specifically activity in the nucleus accumbens. This brain region, typically associated with reward and motivation, signals a fundamental need for attachment figures, akin to the body's thirst for water.

Protest and Despair

These are two primary, often oscillating, reactions to loss. Protest involves active searching or refusal to accept the loss, driven by a 'go' response. Despair is a withdrawal, an acknowledgment of the finality of the loss, which serves to conserve vital resources by stopping futile searching behaviors.

Transmutation of Grief

This concept involves taking the intense energy of protest and despair and transforming it into functional actions and feelings. It means adapting and evolving the internal relationship with the deceased, allowing their memory to remain active in a way that supports moving forward in life.

Dual Process Model of Bereavement

This model describes healthy grieving as an oscillation between two types of coping: confronting the loss itself (loss-oriented stressors like sadness and yearning) and engaging with life's demands and rebuilding (restoration-oriented stressors like new roles and tasks). The ability to move back and forth between these is indicative of healthy adjustment.

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What is the difference between 'grief' and 'grieving'?

Grief is the immediate, in-the-moment emotional, physical, and mental reaction to loss, while grieving is the process of how grief changes and evolves over time as one learns to live with the loss.

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Does knowing a death is coming make the grieving process easier?

While having closure conversations can be helpful for later reflection, anticipating a loss doesn't necessarily change the implicit attachment biology, which struggles to accept the finality of death, making the learning process difficult regardless.

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How is the brain's dopamine system involved in grief?

The dopamine system, particularly the nucleus accumbens, is activated during yearning for a lost loved one, indicating a powerful 'wanting' or 'thirst' for the attachment figure, similar to basic survival needs like water.

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What are the two main types of reactions to loss, and what is their purpose?

The two main reactions are protest (active searching, refusal to accept) and despair (withdrawal, acknowledging finality). Protest aims to find the lost one, while despair conserves energy by stopping futile searching behaviors.

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Is it medically risky to be in a state of grief?

Yes, grief is a medically risky time; for example, a person is 21 times more likely to have a heart attack on the day a loved one dies, and men are nearly twice as likely to have a fatal heart attack in the first three months after their wife's death.

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How does culture influence the grieving process?

Many modern cultures lack the established systems, often religious, that historically provided a framework and social support for understanding and managing the intense emotions of grief, leaving individuals adrift.

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How can one cope with the physical sensations of grief?

Engaging in physical practices like progressive muscle relaxation can help the body shift into a different physiological state, thereby aiding in coping with the physical and emotional demands of grief.

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Are the 'stages of grief' a rigid progression?

No, modern grief research shows that grief is not a linear progression through fixed stages like disbelief, anger, and acceptance; rather, these responses can occur simultaneously, in different orders, and fluctuate over time.

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How is grieving a death by suicide different from other forms of loss?

Grieving suicide is often more challenging due to its sudden, violent, and unexpected nature, frequently leading to 'would have, could have, should have' rumination, which traps the grieving person in an infinite loop of unanswerable questions.

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Can contemplating death be a beneficial practice?

Yes, contemplating death, whether through philosophical or spiritual frameworks, can help reduce grief severity by providing a way to understand the role of death in life and prepare one to live more authentically and appreciate abundance.

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What is the 'dual process model of bereavement'?

This model describes healthy grieving as an oscillation between confronting the loss itself (loss-oriented) and engaging with life's demands and rebuilding (restoration-oriented), rather than a linear progression.

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Does avoidance help in the grieving process?

No, avoidance of conversations, places, or reminders related to the deceased can actually make the grieving process harder by preventing the necessary learning and adjustment to life without the loved one.

1. Transmute Grief: Protest & Despair

Actively engage with feelings of protest (refusal to let go) and despair (helplessness) by acknowledging them and then transforming these emotions into actions that honor the memory of the lost person or role while enabling forward movement in life.

2. Cultivate Internal Bonds

Actively maintain an internal relationship with the deceased by engaging in thoughts or actions that keep their memory alive, like talking to them or considering their perspective, as this internal bond is deeply encoded in the brain and can evolve over time.

3. Give Permission for Joy & Life

Grant yourself permission to experience joy, pursue new relationships, and engage in life’s pleasures without guilt, recognizing that this honors the deceased’s values and allows you to live a full life, rather than being a betrayal.

4. Oscillate: Loss & Life Restoration

Develop the capacity to oscillate between fully experiencing loss-related emotions and engaging in practical life-restoration tasks, as this flexible movement between grief and daily functioning is a hallmark of healthy adaptation.

5. Prioritize Support & Health

Actively seek social support and prioritize your physical health during bereavement, as grief is a medically risky period that can impact the body, and others can help with physiological regulation and health reminders.

6. Develop Diverse Coping Toolkit

Develop a range of coping strategies for managing waves of grief, including the ability to strategically suppress emotions in certain contexts (like a work meeting) and to allow full emotional expression with social support at other times, adapting to the moment’s needs.

7. Use Progressive Muscle Relaxation

Engage in Progressive Muscle Relaxation (PMR) by tensing and relaxing various muscle groups, from head to toe, to become aware of and alleviate physical tension, which can help soothe the body and manage intense grief.

8. Avoid ‘If Only’ Ruminations

Actively disengage from repetitive ‘if only’ thoughts, especially after a suicide, as these unanswerable questions prevent adaptation and shift focus away from living in the present reality of the loss.

9. Shift Environment, Disrupt Thoughts

When experiencing persistent, unhelpful rumination, physically change your environment, such as stepping outside, as this shift can help interrupt negative thought patterns and re-engage you with the present moment.

10. Contemplate Life & Death

Reflect on and develop an understanding of life and death, perhaps through philosophical or religious frameworks, in advance of personal loss, as this can provide a helpful structure and potentially reduce grief severity.

11. Practice Death Awareness

Regularly contemplate your own mortality, not with terror, but as a practice to motivate living a life aligned with your values, expressing love, forgiveness, and gratitude, and preparing to be ‘okay’ with the end.

12. Prepare Post-Death Wishes

Create and regularly update a document detailing your wishes and messages for loved ones after your death, as this can alleviate confusion and emotional burden for them during their grieving process.

13. Avoid Grieving Alone

Actively seek out support and avoid grieving in isolation, as this helps prevent self-blame and fosters healthier learning about death as an inherent part of life.

14. Confront Grief Avoidance

Resist the urge to avoid reminders of the deceased, such as places or belongings, because avoidance can hinder the necessary learning process of adapting to life after loss and potentially prolong grief.

15. Seek Help for Worsening Grief

If your grief symptoms are consistently deteriorating over time, rather than showing any signs of adaptation, seek professional psychological help, as this indicates a need for intervention to return to a typical grieving trajectory.

16. Differentiate Grief & Grieving

Understand that ‘grief’ is a momentary emotional wave, while ‘grieving’ is the long-term process of learning to live with loss, helping to accept that waves of grief will always arise but the overall trajectory can be one of adaptation.

17. Regulate Protest with Movement

When experiencing the ‘amped up’ physical state of protest, engage in physical activity like running or calming practices such as yoga and breathing exercises to physically soothe yourself and regulate your heart rate and emotions.

18. Pre-Loss Closure Conversations

Engage in closure conversations with terminally ill loved ones, expressing sentiments like ‘I love you,’ ’thank you,’ ‘I forgive you,’ and ‘please forgive me,’ as these conscious goodbyes can aid in later reflection and grieving.

19. Don’t Shorten Grief Process

Refrain from actively trying to shorten or bypass the grieving process, as attempting to rush through it can paradoxically prolong the experience and impede natural adaptation.

Grief is the natural response to loss. It is a natural, physical, emotional, mental, just reaction to the death of someone very close to us.

Dr. Mary-Frances O'Connor

The belief that they will always be there does not respond to logical thinking.

Dr. Mary-Frances O'Connor

The amount of energy it takes to create the blood pressure and the cortisol to reach out like that, and so that despair does actually have a function, that withdrawal is for good reason.

Dr. Mary-Frances O'Connor

Grief is not a disease, grief is totally natural, but you know, pregnancy is not a disease, pregnancy is totally natural, but no one would say it's not physiological.

Dr. Mary-Frances O'Connor

The only way to prolong the process is by trying to shorten it.

Andrew Huberman

Until we can know loss, we can't know abundance either, and when we know loss, it takes smaller and smaller things for it to feel abundant.

Dr. Mary-Frances O'Connor

Progressive Muscle Relaxation for Grief

Dr. Mary-Frances O'Connor
  1. Briefly contract different muscle groups in your body (e.g., fists, then forearms).
  2. Relax the contracted muscle groups.
  3. Become aware of the difference between the clenched and relaxed state.
  4. Work through muscle groups from head to toe, using guided audio if helpful.

Shifting Environment to Cope with Rumination

Dr. Mary-Frances O'Connor
  1. Recognize when you are engaging in repetitive, unhelpful 'if only' thoughts.
  2. Literally get up and change your physical environment (e.g., walk outside).
  3. Allow this physical shift to help change your thought patterns and bring you back to the present moment.

Contemplating Death as a Life-Enhancing Practice

Andrew Huberman
  1. Engage in a self-directed relaxation practice, such as yoga nidra or non-sleep deep rest (NSDR).
  2. During the first long exhale, imagine taking your last breath, aiming to be present for it.
  3. Acknowledge the finite nature of time and life.
  4. Use this realization to lean into life more fully, appreciating moments and living with greater presence.

Preparing for Loved Ones After Death

Andrew Huberman
  1. Create a document, separate from a will of assets, containing notes and wishes for loved ones after your passing.
  2. Include things you would want them to know, or how you would want them to remember you.
  3. Update this document regularly, adding or removing content as your feelings or relationships evolve.
  4. Ensure a trusted person has secure access to this document (e.g., password-protected with shared access).
21 times
Increased risk of heart attack on the day a loved one dies Compared to any other day of one's life.
Nearly twice as likely
Increased risk of fatal heart attack for men In the first three months after the death of his wife, compared to a man who remains married.
1.8 times
Increased risk of fatal heart attack for women After the death of her husband, compared to a woman who remains married.
One-third
Percentage of 20-year-old college students who know someone who died by suicide Observed in Dr. O'Connor's psychology of death and loss class.